Old rivals/buddies Cable and Deadpool will meet for the first time ... again ... in May's Cable #3 by Gerry Duggan and Phil Noto. The twist is, of course, courtesy of the new, younger version of Cable.
"Deadpool considers Cable one of his best friends, but the young star of this new ongoing series will be a very different Cable than the one he remembers," reads Marvel's description. "Not yet the grizzled old veteran Deadpool has teamed up with in the past, Nathan Summers will be meeting Deadpool for the first time in an adventure that will prove that this is one friendship that is destined to be!: