On the one hand, it seems ridiculous to speculate that the four super beings created by X-Men villain Apocalypse are the same four horsemen mentioned in the Bible. Clearly, they just share the same names (Death, Family, War and Pestilence), right...? After all, there have been multiple
characters taking on each role at various times (at various times, Angel, Wolverine, Gambit and Psylocke have all taken up the "Death" persona).
And yet... the Bible never actually explicitly said that its horsemen weren't genetically-modified super beings who were working for a self-important arch-villain with a massive mouth, did it? I think you see my point.